Wibmer, Constantinos KurtAyres, FrancesHermanus, TandileMadzivhandila, MashuduKgagudi, PrudenceOosthuysen, BrentLambson, Bronwen E.De Oliveira, TulioVermeulen, MarionVan der Berg, KarinRossouw, Theresa M.Boswell, Michael T.Ueckermann, VeronicaMeiring, SusanVon Gottberg, AnneCohen, CherylMorris, LynnBhiman, Jinal N.Moore, Penny L.2021-04-072021-04Wibmer, C.K., Ayres, F., Hermanus, T. et al. SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma. Nature Medicine 27, 622–625 (2021). https://doi.org/10.1038/s41591-021-01285-x.1078-8956 (print)1546-170X (online)10.1038/s41591-021-01285-xhttp://hdl.handle.net/2263/79329Supplementary Information: Supplementary Figs. 1 and 2SARS-CoV-2 501Y.V2 (B.1.351), a novel lineage of coronavirus causing COVID-19, contains substitutions in two immunodominant domains of the spike protein. Here, we show that pseudovirus expressing 501Y.V2 spike protein completely escapes three classes of therapeutically relevant antibodies. This pseudovirus also exhibits substantial to complete escape from neutralization, but not binding, by convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and foreshadows reduced efficacy of spike-based vaccines.en© The Author(s), under exclusive licence to Springer Nature America, Inc. 2021Infectious diseasesCOVID-19 pandemicCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Postprint Article