Zanella, Virgilio GonzalesWagner, Vivian PetersenSchmidt, Tuany RafaeliThieme, StefanieCorrea, CintiaFonseca, Felipe PaivaRigon, PettalaBarra, Marinez BizarroKroef, Ricardo GallicchioVargas, Pablo AgustinMartins, Manoela Domingues2022-05-202022-05-202021-05Zanella, V.G., Wagner, V.P., Schmidt, T.R., Thieme, S., Correa, C., Fonseca, F.P, et al. Salivary gland cancer in Southern Brazil: a prognostic study of 107 cases. Medicina Oral Patologia Oral y Cirugia Bucal 2021 May 1;26 (3):e393-403.1698-4447 (print)1698-6946 (online)10.4317/medoral.24248https://repository.up.ac.za/handle/2263/85590BACKGROUND : Salivary gland cancers (SGC) represent an uncommon group of heterogeneous tumors. We performed a retrospective survey of SGC diagnosed in a reference center for treatment of malignant tumors from the south of Brazil aiming to determine the prognostic value of demographic, clinic and pathologic features. MATERIAL AND METHODS : Cases diagnosed as SGC between 2006 and 2016 were retrospectively collected. Medical records were examined to extract demographic, clinic, pathologic and follow-up information. RESULTS : One-hundred and seven cases of SGC were identified. The most common SGC were mucoepidermoid carcinoma (MEC) (n = 39) followed by adenoid cystic carcinoma (AdCC) (n = 29). Among AdCCs, 55.2% of cases were classified as cribriform, 27.6% as tubular and 17.2% as solid. The tubular subtype had the highest percentage of cases with perineural invasion (p=0.01). Among MEC, 61.5% of cases were classified as low grade, 15.4% as intermediate grade and 19.9% as high grade. Low grade MEC had the lowest percentage of cases with perineural invasion (p=0.04). The 5-year survival for loco-regional control, disease-free survival (DFS) and disease-specific survival were 75%, 70% and 84%, respectively. The following features were associated with poor DFS: advanced age (p=0.03), rural residency (p=0.01), being a smoker or former smoker (p=0.01), pain (p=0.03), nodal metastasis (p<0.001), need for chemotherapy (p=0.02), neck dissection (p=0.04), perineural invasion (p=0.01), and being diagnosed with AdCC compared to MEC (p=0.02). CONCLUSIONS : The clinco-demographic and pathologic features identified as prognostic factors reveal the profile of patients at increased risk of recurrence and who would benefit from closer follow-up.en© Medicina Oral S. L.Head and neck neoplasmsNeoplasmsGlandular and epithelialRare diseasesEpidemiologyFollow up studiesSalivary gland cancers (SGC)Article