Mandiwana, VusaniKalombo, LonjiHayeshi, RoseZeevaart, Jan RijnEbenhan, Thomas2021-12-012021-12-012021-04-30Mandiwana, V.; Kalombo, L.; Hayeshi, R.; Zeevaart, J.R.; Ebenhan, T. Preclinical Assessment Addressing Intravenous Administration of a [68Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution. Molecules 2021, 26, 2650. https://DOI.org/ 10.3390/molecules26092650.1420-3049 (print)1420-3049 (online)10.3390/molecules26092650http://hdl.handle.net/2263/82928It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [68Ga]Ga-PSMA- 617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [68Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.en© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.Biodistribution68Ga[68Ga]Ga-PSMA-617-MEIn vivoMicroemulsionMicroPET/CTProstate cancerPSMA-617ToxicityArticle