Oyagbemi, Ademola AdetokunboBolaji-Alabi, Foluso BolawayeAjibade, Temitayo OlabisiAdejumobi, Olumuyiwa AbiolaAjani, Olumide SamuelJarikre, Theophilus AghoghoOmobowale, Temidayo OlutayoOla-Davies, Olufunke EuniceSoetan, Kehinde OlugboyegaAro, Abimbola ObemisolaEmikpe, Benjamin ObukowhoSaba, Adebowale BenardAdedapo, Adeolu AlexOyeyemi, Matthew OlugbengaNkadimeng, Sanah MalomileKayoka-Kabongo, Prudence NgalulaMcGaw, Lyndy JoyOguntibeju, Oluwafemi OmoniyiYakubu, Momoh Audu2021-09-022020-12Oyagbemi AA, Bolaji-Alabi FB, Ajibade TO, et al. Novel antihypertensive action of rutin is mediated via inhibition of angiotensin converting enzyme/ mineralocorticoid receptor/angiotensin 2 type 1 receptor (ATR1) signaling pathways in uninephrectomized hypertensive rats. Journal of Food Biochemistry 2020;00:e13534. https://doi.org/10.1111/jfbc.13534.0145-8884 (print)1745-4514 (online)10.1111/jfbc.13534http://hdl.handle.net/2263/81631Hypertension is the most common cardiovascular disease that affects approximately 26% of adult population, worldwide. Rutin is one of the important flavonoids that is consumed in the daily diet, and found in many food items, vegetables, and beverages. Uninephrectomy (UNX) of the left kidney was performed, followed by induction of hypertension. The rats were randomly divided into four groups of 10 rats: group 1—Sham-operated rats; group 2—UNX rats, group 3—UNX-L-NAME (40 mg/kg) plus rutin (100 mg/kg bwt), and groups 4—UNX-L-NAME plus lisinopril (10 mg/kg bwt), orally for 3 weeks. Results revealed significant heightening of arterial pressure and oxidative stress indices, while hypertensive rats treated with rutin had lower expressions of angiotensin converting enzyme (ACE) and mineralocorticoid receptor in uninephrectomized rats. Together, rutin as a novel antihypertensive flavonoid could provide an unimaginable benefits for the management of hypertension through inhibition of angiotensin converting enzyme and mineralocorticoid receptor. PRACTICAL APPLICATIONS : Hypertension has been reported to be the most common cardiovascular disease, affecting approximately 26% of the adult population worldwide with predicted prevalence to increase by 60% by 2025. Recent advances in phytomedicine have shown flavonoids to be very helpful in the treatment of many diseases. Flavonoids have been used in the treatment and management of cardiovascular diseases, obesity and hypertension. The study revealed that rutin, a known flavonoid inhibited angiotensin converting enzyme (ACE), angiotensin 2 type 1 receptor (ATR1), and mineralocorticoid receptor (MCR), comparable to the classic ACE inhibitor, Lisinopril, indicating the novel antihypertensive property of rutin. Therefore, flavonoids such as rutin found in fruits and vegetables could, therefore, serve as an antihypertensive drug regimen. Combining all, functional foods rich in flavonoids could be used as potential therapeutic candidates for managing uninephrectomized hypertensive patients.en© 2020 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article : Novel antihypertensive action of rutin is mediated via inhibition of angiotensin converting enzyme/ mineralocorticoid receptor/angiotensin 2 type 1 receptor (ATR1) signaling pathways in uninephrectomized hypertensive rats. Journal of Food Biochemistry 2020;00:e13534. https://doi.org/10.1111/jfbc.13534. The definite version is available at : http://www.wileyonlinelibrary.com/journal/jfbc.HypertensionMechanism of actionPhytochemicalRutinUninephrectomyAngiotensin converting enzyme (ACE)Angiotensin 2 type 1 receptor (ATR1)Mineralocorticoid receptor (MCR)Veterinary science articles SDG-03SDG-03: Good health and well-beingPostprint Article