Peters, Remco P.H.Manguro, GriffinsOng'wen, Patricia A.Mdingi, Mandisa M.Applegate, Tanya L.Stuart, RobynHarding-Esch, Emma M.Manabe, Yukari C.Ndowa, FrancisVan der Pol, Barbara2026-02-172026-02-172026Peters, R.P.H., Manguro, G., Ong’wen, P.A. et al. 2026, 'Point-of-care testing to strengthen sexually transmitted infection case management in resource-constrained settings', Sexually Transmitted Infections, doi : 10.1136/sextrans-2025-056833.1368-4973 (print)1472-3263 (online)10.1136/sextrans-2025-056833http://hdl.handle.net/2263/108323Syndromic management remains the standard approach for sexually transmitted infection (STI) care in many low-resource settings. Recent advances in point-of-care (POC) diagnostic testing offer the opportunity to improve STI case management by enabling targeted treatment, reducing unnecessary antibiotic use, and strengthening partner services. This educational article summarizes key insights from a symposium organised by the World Health Organization and Gates Foundation at the STI & HIV World Congress 2025. Evidence from modeling studies in Zimbabwe and South Africa demonstrates significant reductions in overtreatment and population-level STI burden with POC test integration. Acceptability among end-users and providers is high, contingent on rapid, confidential testing linked to same-day treatment. The article reviews the current landscape of STI POC tests, including WHO’s REASSURED criteria and target product profiles, and discusses regulatory progress and technical specifications for prequalification. Implementation strategies emphasize integration into existing health services, capacity building, stakeholder engagement and importance of robust quality assurance processes. While cost-effectiveness data remain limited, strategic investment and policy development are essential to scale up STI POC testing. With growing technological feasibility and public health urgency, POC testing represents a paradigm shift in STI management, offering a pathway to more effective, equitable, and sustainable care in resource-constrained settings.en© Author(s) (or their employer(s)) 2026. No commercial re-use.Sexually transmitted infection (STI)Point-of-care testing (POCT)Syndromic managementNeisseria gonorrhoeaeTrichomonas vaginalisChlamydia trachomatisPostprint Article