Heartwater : Past, Present and Future. Workshop (1986 : Kruger National Park, South Africa)Du Plessis, J.L.Malan, LetitiaKowalski, Z.E.Bigalke, R.D.2014-11-192014-11-1920141987Du Plessis, JL, Malan, L & Kowalski, ZE 1987, 'The pathogenesis of heartwater’, Onderstepoort Journal of Veterinary Research, vol. 54, no. 3, pp. 313-318.0330-2465http://hdl.handle.net/2263/42665The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Hypotheses on the pathogenesis of heartwater, which have been published so far, are briefly reviewed. Attempts were made at counteracting the effects of vaso-active substances released by mast cells by treating mice infected with Cowdria ruminantium with antagonists to histamin and serotonin on one hand, and with mast cell stabilizers on the other, but were not successful. Preliminary findings suggest that a hypersensitive type of reaction, triggered by the release of pharmacologically active substances, may possibly be basic to the pathogenesis of heartwater. Complement, and the products of arachidonic acid metabolism, possibly play a role in the release of the vaso-active substances.en©ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). ©University of Pretoria. Dept. of Library Services (digital).Veterinary medicineVeterinary medicine -- South AfricaHeartwater -- South AfricaArticle