Kruger, KarinSaulez, Montague NewtonNeser, J.A.Solberg, K.2008-07-282008-07-282008-03Kruger, K, Saulez, MN, Neser, JA & Solberg K, 2008, 'Acute lead intoxication in a pregnant mare', Journal of the South African Veterinary Association, vol. 79, no. 1, pp. 50-53. [http://www.journals.co.za/ej/ejour_savet.html]0038-2809http://hdl.handle.net/2263/6335Lead (Pb) intoxication in horses is usually a chronic phenomenon with clinical signs associated with central nervous dysfunction. This report gives details of a case of acute Pb intoxication in a 9-year-old American Saddlebred mare with severe, progressive and ultimately fatal neurological deterioration. During the 4 days of hospitalisation, clinical signs progressed from intermittent headshaking and depression to severe, continuous, uncontrollable manic behaviour. At autopsy, three grey-coloured, hard metal particles were present in the gastrointestinal tract and subsequently found to contain 2614 ppm Pb. Lead concentrations in the brain, liver, stomach and kidney were 29, 4, 6 and 2 ppm wet weight, respectively.398170 bytesapplication/pdfenSouth African Veterinary AssociationCerebral dysfunctionEquineLead intoxicationLead poisoning in animalsVeterinary neurologyArticle