Heartwater : Past, Present and Future. Workshop (1986 : Kruger National Park, South Africa)Van Amstel, S.R.Reyers, FredOberem, P.T.Killeen, Valerie M.Matthee, O.Bigalke, R.D.2014-11-192014-11-1920141987Van Amstel, SR, Guthrie, AJ, Reyers, F, Bertschinger, H, Oberem, PT, Killeen, VM & Matthee, O 1987, 'The clinical pathology and pathophysiology of heartwater : a review’, Onderstepoort Journal of Veterinary Research, vol. 54, no. 3, pp. 287-290.0330-24657006535470J-6375-20130000-0001-7729-9918http://hdl.handle.net/2263/42658The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.This paper reviews the available literature on the clinical pathology and pathophysiology of heartwater and makes comparisons with unpublished results obtained from a recent study in experimentally-induced heartwater in calves. The pathophysiological changes seem to center on an increased capillary permeability the result of which is reflected most noticeably in cardiac and lung function. There is a marked drop in cardiac output in severe cases and some workers have recorded a severe drop in diastolic blood pressure in the advanced stage of the disease. Changes in lung function are variable, depending on the stage of the disease, and may change from a respiratory alkalosis in the early febrile stage to a respiratory acidosis in more advanced cases. The basic cause for the increased capillary permeability is not known. The main clinical pathological changes measured include a progressive anaemia, fluctuations in total and differential white cell count, of which an eosinopenia and a lymphocytosis are the most marked, increases in total bilirubin which coincide with darkening of plasma colour, and a drop in total serum proteins mostly shown in the albumin levels.en©ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). ©University of Pretoria. Dept. of Library Services (digital).Veterinary medicineVeterinary medicine -- South AfricaHeartwater -- South AfricaArticle