Teboh-Ewungkem, Miranda I.Woldegerima, Woldegebriel AssefaNgwa, Gideon A.2021-05-042021-04Teboh-Ewungkem, M.I., Woldegerima, W.A. & Ngwa, G.A. 2021, 'Mathematical assessment of the impact of human-antibodies on sporogony during the within-mosquito dynamics of Plasmodium falciparum parasites', Journal of Theoretical Biology, vol. 515, art. 110562, pp. 1-21.0022-5193 (print)1095-8541 (online)10.1016/j.jtbi.2020.110562http://hdl.handle.net/2263/79745We develop and analyze a deterministic ordinary differential equation mathematical model for the within-mosquito dynamics of the Plasmodium falciparum malaria parasite. Our model takes into account the action and effect of blood resident human-antibodies, ingested by the mosquito during a blood meal from humans, in inhibiting gamete fertilization. The model also captures subsequent developmental processes that lead to the different forms of the parasite within the mosquito. Continuous functions are used to model the switching transition from oocyst to sporozoites as well as human antibody density variations within the mosquito gut are proposed and used. In sum, our model integrates the developmental stages of the parasite within the mosquito such as gametogenesis, fertilization and sporogenesis culminating in the formation of sporozoites. Quantitative and qualitative analyses including a sensitivity analysis for influential parameters are performed. We quantify the average sporozoite load produced at the end of the within-mosquito malaria parasite’s developmental stages. Our analysis shows that an increase in the efficiency of the ingested human antibodies in inhibiting fertilization within the mosquito’s gut results in lowering the density of oocysts and hence sporozoites that are eventually produced by each mosquito vector. So, it is possible to control and limit oocysts development and hence sporozoites development within a mosquito by boosting the efficiency of antibodies as a pathway to the development of transmission-blocking vaccines which could potentially reduce oocysts prevalence among mosquitoes and hence reduce the transmission potential from mosquitoes to human.en© 2020 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Journal of Theoretical Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Journal of Theoretical Biology, vol. 515, art. 110562, pp. 1-21, 2021. doi : 10.1016/j.jtbi.2020.110562.Malaria parasitesWithin-mosquitoSporogonyGametogenesisHuman antibodiesTransmission blockingMathematical modellingIngested human antibodiesOocyst densityMosquitoesPostprint Article