Rapoport, Bernardo LeonAnderson, Ronald2023-08-112023-08-112022-02Rapoport, B.L. & Anderson, R. 2022, 'Recent advances, patient selection & challenges in managing cancer patients undergoing treatment with immune checkpoint inhibitors', The Indian Journal of Medical Research, vol. 155, pp. 219-224, doi : 10.4103/ijmr.ijmr_118_22.0971-5916 (print)0975-9174 (online)10.4103/ijmr.ijmr_118_22http://hdl.handle.net/2263/91893This editorial is published on the occasion of World Cancer day - February 4, 2022.Cancer immunotherapy with humanized monoclonal antibodies (mAbs) that target co-inhibitory immune checkpoint molecules (ICMs) is the most meaningful advance in the management of malignant diseases in recent years. This has coincided with the acquisition of eloquent, cutting edge insights into the molecular mechanisms, which regulate cell–cell interactions that are fundamental to maintain a balanced, well-synchronized human immune system. These developments have also revitalized the practice of immunotherapy, especially the realization of novel immunomodulatory therapeutic modalities that have the potential to restore weakened anti-cancer immune responses.en© 2022 Indian Journal of Medical Research.CancerMolecular mechanismsImmunotherapyEditorialCancer immunotherapyMonoclonal antibodies (mAbs)Immune checkpoint molecules (ICMs)SDG-03: Good health and well-beingArticle