Schultz, R.A. (Rowena Anitra)Fourie, NielBasson, Karin M.Labuschagne, LeonieBoomker, Jacob Diederik Frederik2012-12-122012-12-1220122001Schultz, RA, Fourie, N, Basson, KM, Labuschagne, L & Prozesky, L 2001, 'Effect of pavetamine on protein synthesis in rat tissue’. Onderstepoort Journal of Veterinary Research, vol. 68, no. 4, pp. 325-330.0030-2465http://hdl.handle.net/2263/20688The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat v.9 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Pavetamine, the active principle of plants causing gousiekte in ruminants, was found in this study to be an inhibitor of protein synthesis in the rat heart. Sprague-Dawley rats were injected intra-peritoneally with 8-10 mg/kg pavetamine and the levels of protein synthesis in the different organs determined utilizing L-[4-³H]phenylalanine incorporation. In contrast to the more than 23% inhibition found in heart tissue at 4, 24 and 48 h after administration of pavetamine, the effect on the kidney, liver, spleen, intestine and skeletal muscle was minimal or returned to pretreatment levels within 48 h. These results may offer an explanation for the clinical signs observed in ruminants with gousiekte, where the heart only is affected.© ARC-Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © University of Pretoria. Dept of Library Services (digital).Veterinary medicineGousiektePavetaminePolyamineProtein synthesis inhibitionRatsVeterinary medicine -- South AfricaArticle