Kali, Gugu T.J.Pillay, ShaktiPepper, Michael SeanHorn, Alan R.2022-09-142022-09-142021-12KAli, G.T., Pillay, S. & Pepper, M.S. et al. 2021, 'Questions about the HELIX trial', Lancet Global Health, vol. 9, no. 12, pp. e1653., doi : 10.1016/S2214-109X(21)00490-3.2214-109X (online)10.1016/S2214-109X(21)00490-3https://repository.up.ac.za/handle/2263/87178In the HELIX study, Sudhin Thayyil and colleagues suggested that all low-income and middle-income countries (LMICs) should immediately suspend use of cooling in neonates. The reported absence of benefit and increased mortality in neonates who were cooled are in contrast to our experience and the findings in meta-analyses in LMICs.en© 2021 The Author(s). This is an Open Access article under the CC BY-NC-ND 4.0 license.HELIXCoolingLow- and middle-income countries (LMICs)NeonatesArticle