Salvador-Oke, Kafilat TaiwoPitout, Johann D.D.Peirano, GiseleStrydom, Kathy-AnneKingsburgh, ChanelEhlers, Marthie MagdaleenKock, Marleen M.2024-10-222024-10-222024-11Salvador-Oke, K.T., Pitout, J.D.D., Peirano, G. et al. Klebsiella pneumoniae with carbapenemases: high prevalence of sequence type 307 with blaOXA181 in South African community hospitals. European Journal of Clinical Microbiology & Infectious Diseases 43, 2239–2244 (2024). https://doi.org/10.1007/s10096-024-04947-z.0934-9723 (print)1435-4373 (online)10.1007/s10096-024-04947-zhttp://hdl.handle.net/2263/98695DATA AVAILABILITY : No datasets were generated or analysed during the current study.This study investigated the molecular characteristics of urinary carbapenemase-producing Klebsiella pneumoniae isolates (n = 194) in Gauteng, South Africa, using simple, cost-effective PCR methodologies. Extensively drug resistant (XDR) ST307 with blaOXA-181 on IncX3 plasmids was endemic in Gauteng community hospitals leaving limited options for treating in- and outpatient urinary tract infections. High-level ceftazidime/avibactam resistance was detected among isolates harbouring blaOXA-48-like including blaOXA-181. These findings highlighted the need for genomic methodologies suitable for lower- and middle-income countries to track XDR clones and plasmids in community hospitals. Such results will aid with treatment and stewardship strategies.en© The Author(s) 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License.Klebsiella pneumoniaeGauteng Province, South AfricaExtensively drug resistant (XDR)Carbapenemase-producing Klebsiella pneumoniaeHigh-risk clone ST307IncX3 plasmidbla OXA-181Low- and middle-income countries (LMICs)SDG-03: Good health and well-beingArticle