Dhanraj, Priyanka;Pitere, R.Pepper, Michael Sean2021-09-082021-09-082021-03Dhanraj, P, Pitere, R & Pepper, MS 2021, 'The impact of obesity on the cellular and molecular pathophysiology of COVID-19', South African Medical Journal, vol. 111, no. 3, pp. 211-214.0256-9574 (print)2078-5135 (online)10.7196/SAMJ.2021.v111i3.15398http://hdl.handle.net/2263/81715Emerging evidence reveals a strong association between COVID-19 and obesity in terms of disease severity, need for hospitalisation and risk of mortality. In this review, we discuss cellular and molecular mechanisms potentially contributing to the pathophysiology of COVID-19 in obese patients. Understanding the relationship between COVID-19 and obesity is pertinent for the clinical management of these patients.en© 2020 Health & Medical Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial Works License (CC BY-NC 3.0).ObesityImmune responseCOVID-19 pandemicCoronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Angiotensin-converting enzyme-2 (ACE2)Article