De Waal, H.L.Pretorius, T.P.Du Toit, P.J.2017-02-232017-02-2320171941De Waal, HL & Pretorius, TP 1941, 'South African Senecio alkaloids. Part 6. The toxic alkaloids of Senecio scleratus sp. nov. Schweikerdt’, Onderstepoort Journal of Veterinary Science and Animal Industry, vol. 17, nos. 1 & 2, pp. 181-190.0330-2465http://hdl.handle.net/2263/59150The articles have been scanned in colour with a HP Scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.(1) Senecio sceleratus sp. nov. 'Schweickerdt is an extremely toxic Senecio species. It contains at least three more or less toxic alkaloids, viz., isatidine, retrorsine and a new alkaloid, sceleratine, (2) Sceleratine, C₁₈H₂₇O₇N, crystallizes with one molecule of water of of crystallization from water and apparently three molecules of ethanol of crystallization from ethyl alcohol. M.P. 178°C, [α]D/21 = +54·0° (ethanol). (3) Upon catalytic hydrogenation sceleratine undergoes hydrogenolysis at the B-hydroxyl and retronecanol and sceleranecic dilactone acid are isolated. (4) Hydrolysis of sceleratine leads to the isolation of the well-known necine base, retronecine and a new dilactone necic acid viz. sceleranecic acid. (5) Sceleranecic acid has the formula C₁₀H₁₄O₅, the m.p. 156°C. (also 213°C.) and [α]24/D = -9.3 (water). (6) Sceleratine is bitter, fairly soluble in water and readily forms addition compounds with hydrochloric acid, nitric acid, picric acid, perchloric acid, methyl-iodide and aurichloride. (7) Experiments to determine the relative toxicity of the alkaloids mentioned are being carried out.en© 1941 ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © 2017 University of Pretoria. Dept. of Library Services (digital).AlkaloidsVeterinary medicine -- South AfricaArticle