Adawaren, Emmanuel OluwasegunMukandiwa, LillianNjoya, Emmanuel MfotieBekker, LizetteDuncan, N.M. (Neil)Naidoo, Vinny2018-08-022018-09Adawaren, E.O., Mukandiwa, L., Njoya, E.M. 2018, 'The use of liver slices from the Cape vulture (Gyps coprotheres) to better understand the role of liver toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) in vultures', Environmental Toxicology and Pharmacology, vol. 62, pp. 147-155.1382-6689 (print)1872-7077 (online)10.1016/j.etap.2018.07.001http://hdl.handle.net/2263/66064Diclofenac, a non-steroidal anti-inflammatory drug (NSAID) was responsible for the death of millions of vultures on the Asian subcontinent, following the consumption of diclofenac contaminated carcasses. The aim of this research was to establish if liver slices could serve as an alternate means of predicting the toxicity of NSAIDs in Gyps vultures. The Cape vulture liver slices was prepared and incubated with four NSAIDs for 6 h. A percent clearance of 1.0 ± 0.253, 0.58 ± 0.153, 0.961 ± 0.312 and 1.242 ± 0.406 (%/h*g) was attained for diclofenac, carprofen, ketoprofen and meloxicam respectively. Both meloxicam and diclofenac exerted toxic effects on the hepatic cells. Protein content indicated that the vulture tissue had lower enzyme levels than expected for an animal of its size. The poor distinction between the ex vivo hepatic percent clearance of meloxicam and diclofenac indicates that liver slices is not an ideal model to investigate NSAIDs toxicity in Cape vulture.en© 2018 Elsevier B.V.. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Environmental Toxicology and Pharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Environmental Toxicology and Pharmacology, vol. 62, pp. 147-155, 2018. doi : 10.1016/j.etap.2018.07.001.DiclofenacMeloxicamLiver slicesCape vulture (Gyps coprotheres)Percent clearanceToxicityNon-steroidal anti-inflammatory drug (NSAID)Postprint Article