Danquah, Cynthia AmaningMinkah, Prince Amankwah BaffourAgana, Theresa A.Moyo, PhanankosiOfori, MichaelDoe, PeaceRali, SibusisoJunior, Isaiah Osei DuahAmankwah, Kofi BonsuSomuah, Samuel OwusuNugbemado, Isaac NewtonMaharaj, Vinesh J.Bhakta, SanjibGibbons, Simon2023-09-212023-09-212022-07-13Danquah, C.A.; Minkah, P.A.B.; Agana, T.A.; Moyo, P.; Ofori, M.; Doe, P.; Rali, S.; Osei Duah Junior, I.; Amankwah, K.B.; Somuah, S.O.; et al. The Phytochemistry and Pharmacology of Tulbaghia, Allium, Crinum and Cyrtanthus: ‘Talented’ Taxa from the Amaryllidaceae. Molecules 2022, 27, 4475. https://DOI.org/10.3390/molecules27144475.1420-3049 (online)10.3390/molecules27144475http://hdl.handle.net/2263/92376Table S1: Compounds from Tulbaghia. Reference [345] is cited in the Supplementary Materials.Amaryllidaceae is a significant source of bioactive phytochemicals with a strong propensity to develop new drugs. The genera Allium, Tulbaghia, Cyrtanthus and Crinum biosynthesize novel alkaloids and other phytochemicals with traditional and pharmacological uses. Amaryllidaceae biomolecules exhibit multiple pharmacological activities such as antioxidant, antimicrobial, and immunomodulatory effects. Traditionally, natural products from Amaryllidaceae are utilized to treat non-communicable and infectious human diseases. Galanthamine, a drug from this family, is clinically relevant in treating the neurocognitive disorder, Alzheimer’s disease, which underscores the importance of the Amaryllidaceae alkaloids. Although Amaryllidaceae provide a plethora of biologically active compounds, there is tardiness in their development into clinically pliable medicines. Other genera, including Cyrtanthus and Tulbaghia, have received little attention as potential sources of promising drug candidates. Given the reciprocal relationship of the increasing burden of human diseases and limited availability of medicinal therapies, more rapid drug discovery and development are desirable. To expedite clinically relevant drug development, we present here evidence on bioactive compounds from the genera Allium, Tulgbaghia, Cyrtanthus and Crinum and describe their traditional and pharmacological applications.en© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.AmaryllidaceaeAlkaloidsAlliumCrinumTulbaghiaCyrtanthusPhytochemicalsNatural productsPharmacological activityDrug discoveryArticle