Janse van Rensburg, EstrelitaEngelbrecht, SusanVan Heerden, Willem Francois PetrusRaubenheimer, E.J.Schoub, Barry D.2007-07-032007-07-031996-03Van Rensburg, EJ, Engelbrecht, S, Van Heerden, WFP, Raubenheimer, EJ & Schoub, BD 1996, 'Human papillomavirus DNA in oral squamous cell carcinomas from an African population sample', Anticancer Research, vol. 16, no. 2, pp. 969-973. [http://www.iiar-anticancer.org/research/research_index.htm]0250-7005http://hdl.handle.net/2263/2867This article was co-written by Prof Janse van Rensburg and Prof Van Heerden before they joined the University of Pretoria.BACKGROUND: The incidence of oral squamous cell carcinoma (OSCC) is on the increase in developing countries. MATERIALS AND METHODS: Formalin fixed paraffin embedded blocks of OSCCs from a black South African population sample of peri-urban and rural origin were selected as follows: Group 1 - 57 OSCCs with a mean age of 59 years; Group 2 - 43 OSCCs all cases younger than 40 years; Group 3 - 46 OSCCs with blocks containing only tumour tissue without any normal epithelium and Group 4, a control group of 38 non-neoplastic epithelial lesions. Type specific primers were used in a standard PCR to amplify a segment of the E6 region of HPV 6, 11, 16 and 18. RESULTS: HPV 11 and 16 DNA were found in one sample each from groups 1 and 2 respectively. CONCLUSION: HPV is not an etiologic factor in the development of OSCC in the population studied.8503 bytesapplication/pdfenInternational Institute of Anticancer Research. The publisher prohibits open access to the full text of this article.Oral squamous cell carcinomaDeveloping countriesMouth -- Cancer -- Blacks -- South AfricaPapillomaviruses -- South AfricaArticle