Van Coller, RiaanSlabbert, PieterSchutte, Clara-Maria2015-08-192015-08-192014-10Van Coller, R, Slabbert, P, Vaidyanathan, J & Schutte, C 2014, 'Successful treatment of disabling paroxysmal nonkinesigenic dyskinesia with deep brain stimulation of the globus pallidus internus', Stereotactic and Functional Neurosurgery, vol. 92, no. 6, pp. 388-392.1011-6125 (print)1423-0372 (online)10.1159/000365226http://hdl.handle.net/2263/49377Paroxysmal nonkinesigenic dyskinesia (PNKD) causes episodes of treatment-resistant involuntary movements. Previous case reports showed effective treatment of PNKD with deep brain stimulation (DBS). We report 2 patients in whom DBS was highly successful when other treatment modalities had failed. METHODS : Two patients aged 34 and 24 years with a longstanding history of PNKD were treated with globus pallidus internus (GPi) DBS. Motor effects were monitored and followed up postoperatively and again at 6 months after surgery. RESULTS : Both patients responded very well to GPi DBS with complete suppression of dyskinesia after surgery in 1 patient and in the second after an additional adjustment of stimulation. CONCLUSION : GPi DBS might be an effective alternative treatment modality for PNKDen© 2014 S. Karger AG, BaselParoxysmal dyskinesiaParoxysmal nonkinesigenic dyskinesia (PNKD)Deep brain stimulation (DBS)Globus pallidus internus (GPi)Postprint Article