Ally, Mahmood Moosa Tar MahomedHodkinson, Bridget2016-06-142016-06-142016Ally, MMTM & Hodkinson, B 2016, 'Rheumatoid Arthritis', South African Family Practice, vol. 58, no. 2, pp. 11-17.2078-6190 (print)2078-6204 (online)http://hdl.handle.net/2263/53105Immune-mediated inflammatory disorders include a clinically diverse group of conditions sharing similar pathogenic mechanisms. Conditions such as rheumatoid arthritis, psoriasis, spondyloarthropathy, inflammatory bowel disease and connective tissue diseases are characterised by immune dysregulation and chronic inflammation. This review will focus immuno-pathogenic mechanisms, aspects of early disease, co-morbidity and therapy in rheumatoid arthritis.en© 2016 The Author(s). Open Access article distributed under the terms of the Creative Commons License [CC BY-NC-ND 4.0].Immune dysregulationChronic inflammationDiseasesRheumatoid arthritis (RA)Article