Stadler, P.Van Amstel, S.R.Verwoerd, Daniel Wynand2014-10-022014-10-0220141989Stadler, P & Van Amstel, SR 1989, 'Adverse effects of a proposed equine sublethal endotoxin model', Onderstepoort Journal of Veterinary Research, vol. 56, no. 3, pp. 207-209.0330-2465http://hdl.handle.net/2263/42195The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.Commercially available Escherichia coli 055: B5 lipopolysaccharide was administered intravenously experimentally at a dosage of 10 µg/kg to 2 horses. Various clinical and clinico-pathological parameters were monitored before and after the endotoxin administration. Because of a hopeless prognosis, and for humane reasons, euthanasia was applied on both horses 6 h after administration. Values recorded for the different parameters, including the blood lactate level, were consistent with a lethal condition. It would appear that an intravenous dose of 10 µg/kg of endotoxin is potentially lethal to horses.en©ARC - Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). ©University of Pretoria. Dept. of Library Services (digital).Veterinary medicineVeterinary medicine -- South AfricaArticle