Xenoulis, P.G.Zoran, D.L.Fosgate, Geoffrey TheodoreSuchodolski, J.S.Steiner, J.M.2017-01-232017-01-232016-11Xenoulis, PG, Zoran, DL, Fosgate, GT, Suchodolski, JS & Steiner, JM 2016, 'Feline exocrine pancreatic insufficiency : a retrospective study of 150 cases', Journal of Veterinary Internal Medicine, 30, no. 6, pp. 1790-1797.0891-6640 (print)1939-1676 (online)10.1111/jvim.14560http://hdl.handle.net/2263/58596Some of the results of this study were presented at the 2012 American College of Veterinary Internal Medicine Forum, New Orleans, LA.BACKGROUND : Little information is available about the clinical presentation and response to treatment of cats with exocrine pancreatic insufficiency (EPI). OBJECTIVES : To describe the signalment, clinical signs, concurrent diseases, and response to treatment of cats with EPI. ANIMALS : One hundred and fifty cats with EPI. METHODS : Retrospective case series. RESULTS : Questionnaires were sent to 261 veterinarians, and 150 (57%) were returned with data suitable for statistical analysis. The median age of the cats with EPI was 7.7 years. The median body condition score was 3 of 9. Ninety-two of 119 cats (77%) had hypocobalaminemia, and 56 of 119 cats (47%) had increased and 6 of 119 cats (5%) had decreased serum folate concentrations. Clinical signs included weight loss (91%), unformed feces (62%), poor hair coat (50%), anorexia (45%), increased appetite (42%), lethargy (40%), watery diarrhea (28%), and vomiting (19%). Eighty-seven cats (58%) had concurrent diseases. Treatment response was reported to be good in 60%, partial in 27%, and poor in 13% of 121 cats. Trypsin-like immunoreactivity <4 lg/L was associated with a positive response to treatment (OR, 3.2; 95% CI, 1.5–7.0; P = .004). Also, cobalamin supplementation improved the response to treatment (OR, 3.0; 95% CI, 1.4–6.6; P = .006). CONCLUSIONS AND CLINICAL IMPORTANCE : Exocrine pancreatic insufficiency in cats often has a different clinical presentation than in dogs. The age range for EPI in cats is wide, and many cats can be ≤5 years of age. Most cats respond well to appropriate treatment for EPI, and cobalamin supplementation appears to be necessary for a good response.en© 2016 The Authors. This article is published under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).CobalaminTreatmentExocrine pancreatic insufficiency (EPI)SignalmentClinical signsConcurrent diseasesCatsArticle