Ismail, NabilaPeters, Remco P.H.Ismail, Nazir AhmedOmar, Shaheed Vally2019-03-082019-03Ismail, N., Peters, R.P.H., Ismail, N.A. et al. 2019, Clofazimine exposure in vitro selects efflux pump mutants and bedaquiline resistance', Antimicrobial Agents and Chemotherapy, vol. 63, no. 1, art. 02141-18, pp. 1-4.0066-4804 (print)1098-6596 (online)10.1128/AAC.02141-18http://hdl.handle.net/2263/68613Six in vitro clofazimine-resistant spontaneous mutants obtained from a wild-type or pyrazinamide-resistant ATCC reference strain were selected to evaluate bedaquiline cross-resistance. The reverse was conducted for bedaquiline mutants. All clofazimine mutants harboring an rv0678 mutation displayed phenotypic cross-resistance. We observed the same for rv0678 bedaquiline mutants; however, atpE bedaquiline mutants showed no phenotypic cross-resistance. This confirms that upfront clofazimine usage may impact subsequent bedaquiline use due to a shared efflux resistance pathway.en© 2019 American Society forMicrobiology. All Rights Reserved.BedaquilineClofazimineCross-resistanceEfflux pump mutantsDrug-resistant tuberculosis (DR-TB)Postprint Article