Van Zyl, MarynaCramer, ElodieSanders, Jan-Stephan F.Leuvenink, Henri G.D.Lisman, TonVan Rooy, Mia-JeanneHillebrands, Jan-Luuk2024-11-192024-11-192024-09Van Zyl, M., Cramer, E., Sanders, J.-S.F. et al. 2024, 'The role of neutrophil extracellular trap formation in kidney transplantation : implications from donors to the recipient', American Journal of Transplantation, vol. 24, art. 101457, pp. 1547-1557, doi : 10.1016/j.ajt.2024.04.018.1600-6135 (print)1600-6143 (online)10.1016/j.ajt.2024.04.018http://hdl.handle.net/2263/99153DATA AVAILABITY STATEMENT: Data availability and sharing are not applicable to the article because no new data was generated or analyzed for this minireview.Kidney transplantation remains the gold standard for patients with end-stage renal disease, but severe donor organ shortage has led to long waiting lists. The utilization of expanded criteria donor kidneys within the category of deceased donors has enlarged the pool of available kidneys for transplantation; however, these grafts often have an increased risk for delayed graft function or reduced graft survival following transplantation. During brain or circulatory death, neutrophils are recruited to the vascular beds of kidneys where a proinflammatory microenvironment might prime the formation of neutrophil extracellular traps (NETs), web-like structures, containing proteolytic enzymes, DNA, and histones. NETs are known to cause tissue damage and specifically endothelial damage while activating other systems such as coagulation and complement, contributing to tissue injury and an unfavorable prognosis in various diseases. In lung transplantation and kidney transplantation studies, NETs have also been associated with primary graft dysfunction or rejection. In this review, the role that NETs might play across the different phases of transplantation, already initiated in the donor, during preservation, and in the recipient, will be discussed. Based on current knowledge, NETs might be a promising therapeutic target to improve graft outcomes.en© 2024 The Author(s). Published by Elsevier Inc. on behalf of American Society of Transplantation & American Society of Transplant Surgeons. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Kidney transplantationInnate immunityPlateletsEndothelial activationDonorRejectionMachine perfusionComplementNeutrophil extracellular traps (NETs)Danger-associated molecular patterns (DAMPs)SDG-03: Good health and well-beingArticle