Selepe, Mamoalosi A.Mthembu, Siyanda T.Sonopo, Molahlehi S.2026-02-132026-02-132025-03Selepe, M.A., Mthembu, S.T. & Sonopo, M.S. 2025, 'Total synthesis of isoflavonoids', Natural Product Reports, vol. 42, no. 3, pp. 540-591, doi : 10.1039/d4np00060a.0265-0568 (print)1460-4752 (online)10.1039/d4np00060ahttp://hdl.handle.net/2263/108207This article is part of the themed collection: Emerging Investigator Review series. DATA AVAILABILITY : No primary research results, software or code have been included and no new data were generated or analysed as part of this review.Isoflavonoids are phenolic compounds with wide structural diversity and a plethora of biological activities. Owing to their structural variation and potential health-promoting and other benefits, they have been targeted for synthesis. Herein, we review the synthesis of natural isoflavonoids belonging to different classes that include isoflavones, isoflavanones, isoflavans, isoflavenes, pterocarpans, rotenoids, coumaronochromones, and coumestans. The synthetic methodologies employed and advancements in synthetic strategies are highlighted.en© The Royal Society of Chemistry 2025. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Article