Garrett, N.Tapley, AsaAndriesen, JessicaSeocharan, IshenFisher, Leigh H.Bunts, LisaEpsy, NicoleWallis, Carole L.Randhawa, April KaurMiner, Maurine D.Ketter, NzeeraYacovone, MargaretGoga, Ameena EbrahimHuang, YundaHural, JohnKotze, PhilipBekker, Linda‑GailGray, Glenda E.Corey, LawrenceUbuntu Study Team2023-05-122023-05-122022-07Garreett, N., Tapley, A., Andriesen, J. et al. 2022, 'High asymptomatic carriage with the Omicron variant in South Africa', Clinical Infectious Diseases, vol. 75, no. 1, pp. e289-e292, doi : 10.1093/cid/ciac237.1058-4838 (print)1537-6591 (online)10.1093/cid/ciac237http://hdl.handle.net/2263/90659We report a 23% asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) Omicron carriage rate in participants being enrolled into a clinical trial in South Africa, 15-fold higher than in trials before Omicron. We also found lower CD4 + T-cell counts in persons with human immunodeficiency virus (HIV) strongly correlated with increased odds of being SARS-CoV-2 polymerase chain reaction (PCR) positive.en© The Author(s) 2022. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.Omicron variantAsymptomatic carriagePWHSouth Africa (SA)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Human immunodeficiency virus (HIV)Polymerase chain reaction (PCR)Article