Schellack, NataliePadayachee, N.2023-02-072023-02-072022Schellack, N. & Padayachee, N. 2022, 'Hypertension', SA Pharmaceutical Journal, vol. 89, no. 1, pp. 19-27.2221-5875 (print)2220-1017 (online)https://repository.up.ac.za/handle/2263/89213This article provides an overview of the changes that have taken place in the diagnosis and management of hypertension over the past decade. Hypertension remains a widespread condition seen in South Africa. The approach to managing hypertension includes necessary lifestyle modifications and a decisive, stepwise escalation process in the pharmacotherapeutic management thereof. Most guidelines are still promoting thiazide diuretics to be the initial (first-line) drug of choice, with the addition of other suitable antihypertensive agents, if necessary, and according to any relevant comorbid conditions.en© Medpharm. This article is licensed under a This article is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.5 South Africa License.HypertensionAntihypertensive agentsFixed-dose combination therapyAngiotensin II-receptor blockersAngiotensin-converting enzyme inhibitorsCalcium-channel blockersArticle