Coetzee, S.Els, H.J.Verwoerd, Daniel WynandBigalke, R.D.Cameron, Colin McKenzieGilchrist, Frances M.C.Morren, A.J.Verster, Anna J.M.Verwoerd, Daniel WynandWalker, Jane B.De Kock, V.E.2016-07-062016-07-0620161976Coetzee, S, Els, HJ & Verwoerd, DW 1976, 'Transmission of jaagsiekte (ovine pulmonary adenomatosis) by means of a permanent epithelial cell line established from affected lungs’, The Onderstepoort Journal of Veterinary Research, vol. 43, no. 3, pp. 133-141.0330-2465http://hdl.handle.net/2263/53771The articles have been scanned in colour with a HP scanjet 5590; 300dpi. Adobe Acrobat XI Pro was used to OCR the text and also for the merging and conversion to final presentyation PDF-Format.An epithelial cell line, designated JS-15. 4, has been established in culture from jaagsiekte lesions and subcultured in vitro for almost 2 years. It exhibits morphological and other features of transformed cells and has been shown by electron microscopy to consist of type B ovine alveolar epithelial cells. Jaagsiekte was successfully transmitted to 3 new-born lambs by the intratracheal injection of cells following immunosuppressive treatment with either anti-thymocyte immunoglobulin alone or combined with anti-macrophage immunoglobulin. Incubation periods as short as 10 weeks were recorded. Evidence was also obtained that natural transmission may result from the inhalation of viable cells.en©1976 ARC-Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). ©2016 University of Pretoria. Department of Library Services (digital).Veterinary medicineVeterinary medicine -- South AfricaArticle