Neville, B.G.Leisewitz, Andrew L.Goddard, AmeliaThompson, P.N. (Peter N.)2010-08-242010-08-242010-03Neville, B, Leisewitz, A, Goddard, A & Thompson, P 2010, 'An evaluation of changes over time in serum creatine kinase activity and C-reactive protein concentration in dogs undergoing hemilaminectomy or ovariohysterectomy', Journal of the South African Veterinary Association, vol. 81, no. 1, pp. 22-26. [http://www.journals.co.za/ej/ejour_savet.html]0038-280967015149757403220452C-3865-2012J-2534-2013http://hdl.handle.net/2263/14737The extent of trauma in a patient can be difficult for a clinician to quantify. A prospective study was performed on 2 groups of dogs undergoing either ovariohysterectomy or hemilaminectomy. The serum activity of creatine kinase and serum concentration of C-reactive protein were evaluated preoperatively and then at 4, 6, 8, 12, 24 and 48 hours postoperatively in both groups. The results were compared statistically both within and between the 2 groups. A wide range of results was found at each time point for both analytes although there were no significant differences for either analyte between the 2 surgical groups preoperatively. Thereafter there were significant differences in creatine kinase activity levels between the 2 groups. C-reactive protein concentration results were very similar in the 2 groups with no statistical difference at any time point. The results of this study suggest that the evaluation of CK and CRP at any one time point in a traumatised animal is of limited value. However, the evaluation of the trend of these 2 analytes, even over a relatively short time period, may allow for useful prognostication in clinical cases.enSouth African Veterinary AssociationC-reactive proteinCreatine kinaseHemilaminectomyOvariohysterectomyTraumaVeterinary medicine -- South AfricaVeterinary traumatologyArticle