Ribeiro Carvalho, Marcus ViniciusRodrigues-Fernandes, Carla IsabellyLopez de Caceres, Cinthia Veronica BardalezMesquita, Ricardo AlvesMartins, Manoela DominguesJose Roman Tager, Elena MariaCarlos, RomanPires, Fabio RamoaRobinson, LiamVan Heerden, Willem Francois PetrusValente, Vitor BonettiCaldeira Xavier-Junior, Jose CandidoBernabe, Daniel GaleraRebelo Pontes, Helder AntonioSoares, Ciro DantasMelo da Costa, Mauro HenriqueVargas, Pablo AgustinFonseca, Felipe Paiva2024-05-302024-05-302023-01Carvalho, M.V.R., Rodrigues-Fernandes, C.I., De Caceres, C.V.B.L. et al. 2023, 'Mantle cell lymphoma involving the oral and maxillofacial region: a study of 20 cases', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 135, no. 1, pp. 101-109, doi : 10.1016/j.oooo.2022.08.018.2212-4403 (print)2212-4411 (online)10.1016/j.oooo.2022.08.018http://hdl.handle.net/2263/96285OBJECTIVE : To investigate the clinicopathologic features of mantle cell lymphoma (MCL) involving the oral and maxillofacial region. METHODS : The MCL cases were retrieved from the pathosis database of 6 pathology laboratories. Original hematoxylin and eosin slides and immunohistochemical reactions were reviewed for confirmation of the initial diagnosis. Clinical data of the cases were obtained from the patients’ pathosis and/or medical charts. RESULTS : Twenty cases were included in the study, showing a male predominance and a mean age of 66 years. The oral cavity (12 cases) and the oropharynx (5 cases) were the most commonly involved subsites. Most cases presented as asymptomatic swellings, with 2 cases showing bilateral involvement of the palate. The classic histologic variant predominated (12/20 cases). All cases expressed CD20 with nuclear cyclin D1 positivity. SOX11 was seen in 9/13 cases, CD5 in 6/16 cases, Bcl2 in 16/19 cases, CD10 in 2/20 cases, and Bcl6 in 4/16 cases. Ki67 showed a mean proliferation index of 40.6%. The Epstein-Barr virus (EBV) was negative in all cases investigated. Follow-up data was available for 7 patients, with 5 currently alive and 2 deceased. CONCLUSION : Mantle cell lymphoma, albeit rare, may manifest in the oral and maxillofacial region. Its histologic heterogeneity demands a high degree of diagnostic skill from pathologists.en© 2022 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 135, no. 1, pp. 101-109, doi : 10.1016/j.oooo.2022.08.018.Mantle cell lymphoma (MCL)Oral and maxillofacial regionSDG-03: Good health and well-beingPostprint Article