Patrick, Sean MarkOmbuki, Winstar MokuaNdambuki, JoanOyaro, Micah O.Bida, MeshackSoh, Pamela X.Y.Prins, Gail S.Argos, MariaBarnhoorn, IreneBrewer, Daniel S.Campbell, RaymondCraddock, JennaEeles, Rosalind A.Jaratlerdsiri, WeerachaiLebelo, Maphuti TebogoLoda, MassimoLouw, MelanieLutsik, PavloMadueke, Ikenna C.Mbeke, Tumisang M.N.Moreira, Daniel M.Mutambirwa, Shingai B.A.Nyaga, Muriuki EliasObida, MartinObida, MuvhulawaOyieko, WillisRadzuma, Mulalo BShirinde, JoyceWalker, Douglas I.Walong, Edwin O.O.Wanjiku, Githui SheilaWedge, David C.Yienya, AllanHayes, Vanessa M.Bornman, Maria S. (Riana)Ngugi, Peter Mungai2026-02-122026-02-122025-12Patrick, S.M., Ombuki, W.M., Ndambuki, J. et al. 2025, 'Prostate cancer clinicopathological presentation in South-East Africa during the 2010 decade', Journal of the National Cancer Institute, vol. 117, no. 12, pp. 2677-2681. https://doi.org/10.1093/jnci/djaf117.0027-8874 (print)1460-2105 (online)10.1093/jnci/djaf117http://hdl.handle.net/2263/108098DATA AVAILABILITY : All data has been provided in the Supplementary Data Resource file and listed by country and/or ancestry. US-SEER data was downloaded from https://seer.cancer.gov/data/access.html.Prostate cancer is the leading cause of cancer-associated death among men across Sub-Saharan Africa, with Southern and East Africa ranking first and fifth globally. However, lack of coordinated national cancer registries has biased data toward single-sourced, averaged, or model estimates. Here, our retrospective study included 8634 South-East African patients diagnosed between 2010 and 2019, which when compared with 71 694 Black and 322 356 White period-matched American men, were over threefold more likely to present with aggressive disease (International Society of Urological Pathology grade groups ≥4: 45.38% vs 21.22% and 21.05%; prostate-specific antigen ≥20 ng/mL: 62.04% vs 17.29% and 11.17%, respectively; all 2-sided P < .0001). East over Southern African men are 1.5 times more likely to present with advanced disease, however, age was not a confounder. Supporting prostate cancer as a major health concern for Africa, our data suggest underestimation in East Africa, while highlighting the need for accurate monitoring, increased awareness, and tailored screening criteria.en© 2025 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND).Prostate cancer (PCa)CauseMenDeathArticle