Tshikalange, Thilivhali EmmanuelMeyer, Jacobus Johannes MarionLall, NamritaMunoz, E.Sancho, R.Van de Venter, MarynaOosthuizen, Vinette2009-04-162009-04-162008Tshikalange, TE, Meyer, JJM, Lall, N, Munoz, E, Sancho, R, Van de Venter, M & Oosthuizen, V 2008, 'In vitro anti-HIV-1 properties of ethnobotanically selected South African plants used in the treatment of sexually transmitted diseases’, Journal of Ethnopharmacology, vol. 119, no. 3, pp. 478-481. [http:// www.elsevier.com/locate/jethpharm]0378-874110.1016/j.jep.2008.08.027http://hdl.handle.net/2263/9662Terminalia sericea extract (IC50 = 92 mg/ml) exhibited a considerable α-glucosidase inhibitory activity which was better than acarbose (IC50 = 131 mg/ml) under our assay conditions. In the reverse transcriptase assay, T. sericea also showed good inhibitory activity (IC50 = 43 mg/ml), which was higher than that of the reference drug, Adriamycin (IC50 = 100 mg/ml). The ethyl acetate extract of Elaeodendron transvaalense exhibited the most potent inhibitory activity in both the NF-κB and Tat assays with inhibitory activity of 76% and 75% respectively at a concentration of 15 mg/ml. The acetone and chloroform extracts of E. transvaalense and Zanthoxylum davyi also showed good activity in the NF-κB and Tat assays.enElsevierElaeodendron transvaalenseTerminalia sericeaZanthoxylum davyiTat assaysNF-κBTerminaliaAntiviral agentsPlant antiviral agentsHIV infectionsAIDS (Disease) -- TreatmentEthnobotany -- South AfricaSexually transmitted diseases -- TreatmentPostprint Article