Kruse, VibekeCocquyt, VeroniqueBorms, MarleenMaes, AlexVan de Wiele, Christophe2014-09-012014-09-012013-02Kruse, V, Cocquyt, V, Borms, M, Maes, A & Van de Wiele, C 2013, 'Serum tumor markers and PET/CT imaging for tumor recurrence detection', vol. 27, no. 2, pp. 97-104.0914-7187 (print)1864-6433 (online)10.1007/s12149-012-0664-6http://hdl.handle.net/2263/41846When confronted with a suspicious rise in CA 15.3 in asymptomatic breast cancer patients following primary treatment and negative or equivocal conventional imaging findings, FDG PET/CT allows assessment of the site and extent of the recurring disease with an accuracy of 83 %. Both FDG PET and FDG PET/CT are superior when compared to CT alone for the purpose of recurrence detection in patients suffering from ovarian carcinoma who have completed primary therapy but demonstrate a rising serum CA-125 level. As the global accuracy of CT alone for detection of recurrence of ovarian cancer approximates 80 %, CT scan should be performed upfront to identify the site of recurrence. When confronted with negative or equivocal CT findings, FDG PET alone or FDG PET/CT should be added. In patients with rising serum CEA levels that have undergone primary treatment for a colorectal carcinoma, both FDG PET and FDG PET/ CT allow detection of tumor recurrence with an accuracy of 95 %, well above that of CT and MRI. Available studies further suggest that FDG/PET findings will affect treatment management in 28–50 % of these patients. The detection rate of both 11C-choline and 18F-choline PET and PET/CT for local, regional, and distant recurrence in prostate carcinoma patients with a biochemical recurrence increases with rising PSA value at the time of imaging and reaches about 75 % in patients with PSA[3 ng/mL. Furthermore, PET and PET/CT with [11C]- and [18F]- choline derivates may be helpful in the clinical setting for optimization of individualized treatment.en© The Japanese Society of Nuclear Medicine 2012. The original publication is available at : http://link.springer.com/journal/12149.Serum tumor markersFDG PET/CTTumor recurrencePET/CTBreast cancerOvarian cancerColorectal cancerProstate carcinomaPositron emission tomography (PET)Computerized tomography' (CT)Fluorine-18-Fluorodeoxyglucose (FDG)Postprint Article