Anderson, RonaldSteel, Helen CarolynCockeran, RianaVon Gottberg, AnneDe Gouveia, L.Klugman, Keith P.Mitchell, Timothy J.Feldman, Charles2008-01-312008-01-312007-11Anderson, R, Steel, HC, Cockeran, R, Von Gottberg, A, De Gouveia, L, Klugman, KP, Mitchell, TJ & Feldman, C 2007, 'Comparison of the effects of macrolides, amoxicillin, ceftriaxone, doxycycline, tobramycin and fluoroquinolones, on the production of pneumolysin by Streptococcus pneumoniae in vitro', Journal of Antimicrobial Chemotherapy, vol. 60, no. 5, pp. 1155-1158. [http://jac.oxfordjournals.org]1460-209110.1093/jac/dkm338http://hdl.handle.net/2263/4329OBJECTIVES: To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline on pneumolysin production by a macrolide-susceptible strain and two macrolide-resistant strains [erm(B) or mef(A)] of Streptococcus pneumoniae. METHODS: Please refer to abstract in article. RESULTS: Only the macrolides/macrolide-like agents caused significant attenuation of the production of pneumolysin, which was evident with all three strains of the pneumococcus. CONCLUSIONS: Macrolides, at sub-MICs, but not other classes of antibiotic, subvert the production of pneumolysin, even in the presence of (and irrespective of the mechanism of) macrolide resistance in S. pneumoniae.124477 bytesapplication/pdfenOxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of Antimicrobial Chemotherapy following peer review. The definitive publisher-authenticated version is available online at: http://jac.oxfordjournals.org/cgi/content/full/60/5/1155.Macrolide resistancePneumococcusProtein synthesisAntibacterial agents -- ResearchDrug resistance in microorganisms -- Genetic aspectsPostprint Article