Nguyen, Thi Kim AnhKoets, Ad P.Santema, Wiebren J.Van Eden, WillemRutten, Victor P.M.G.Van Rhijn, Ildiko2009-09-042009-09-042009Nguyen TKA, et al. The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle. Vaccine (2009), doi:10.1016/j.vaccine.2009.05.0780264-410X10.1016/j.vaccine.2009.05.078http://hdl.handle.net/2263/11171Glycolipids are presented to T cells by human group 1 CD1 proteins, but are not used as subunit vaccines yet. Experimental immunizations with pure mycobacterial glucose monomycolate (GMM) and keyhole limpet haemocyanin (KLH) in cattle, a species which, unlike mice, expresses group 1 CD1, showed that GMM was equally efficient as KLH in generating T cell responses in blood, but not in the draining lymph node. Also, KLH induced strong antibody responses whereas GMM did not. These data suggest that nonoverlapping T cell populations are targeted and demonstrate the potential of glycolipids as a special class of subunit vaccine candidates.enElsevierMycobacterial glucose monomycolateKeyhole limpet haemocyaninCattle -- VaccinationT cellsGlycolipidsPostprint Article