Andre-Levigne, DominikModarressi, AliPepper, Michael SeanPittet-Cuenod, Brigitte2018-02-162018-02-162017-10-15Andre-Levigne, D., Modarressi, A., Pepper, M.S. et al. 2017, 'Reactive oxygen species and NOX enzymes are emerging as key players in cutaneous wound repair', International Journal of Molecular Sciences, vol. 18, art. no. 2149, pp. 1-28.1422-0067 (online)10.3390/ijms18102149http://hdl.handle.net/2263/64003Our understanding of the role of oxygen in cell physiology has evolved from its longrecognized importance as an essential factor in oxidative metabolism to its recognition as an important player in cell signaling. With regard to the latter, oxygen is needed for the generation of reactive oxygen species (ROS), which regulate a number of different cellular functions including differentiation, proliferation, apoptosis, migration, and contraction. Data specifically concerning the role of ROS-dependent signaling in cutaneous wound repair are very limited, especially regarding wound contraction. In this review we provide an overview of the current literature on the role of molecular and reactive oxygen in the physiology of wound repair as well as in the pathophysiology and therapy of chronic wounds, especially under ischemic and hyperglycemic conditions.en© 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).Reactive oxygen speciesNADPH oxidaseNOX enzymesWound repairWound healingChronic woundsWound contractionRe-epithelializationHyperbaric oxygen therapyOxidative stressArticle