Fraser, Evan D.G.Adeyemo, OlanikeAmiot-Carlin, Marie-JosepheAzam-Ali, SayedCaron, PatrickCole, MartinClapp, JenniferDuwayri, MahmudEcheverria, RubenElizondo, CeciliaElver, HilalLehman, BernardRecine, ElisabettaSchonfeldt, H.C. (Hettie Carina)Serraj, RachidSuwa-Eisenmann, AkikoTangermann, StafanWebb, PatrickWright, Iain2025-11-062025-11Fraser, E.D.G., Adeyemo, O., Amiot-Carlin, M.J. et al. 2025, 'Uncertain times require new thinking for agri-food science to ensure food security and nutrition for all', Trends in Food Science and Technology, vol. 165, art. 105261, pp. 1-3, doi : 10.1016/j.tifs.2025.105261.0924-2244 (print)1879-3053 (online)10.1016/j.tifs.2025.105261http://hdl.handle.net/2263/105129DATA AVAILABILITY : No data was used for the research described in the article.For over six decades, international policy has enabled agricultural products to move relatively easily across national borders. Currently, however, the landscape is changing. Deglobalization and the erosion of multilateral principles threaten international food supply chains while climate change is increasingly undermining production. In addition, today's food systems contribute to major environmental and human health problems. The global agri-food research agenda must adapt quickly to these realities. Here we propose that a new research agenda be established based on three principles to help respond to challenging times, promote human rights, sustain gains made in the past, and support greater positive impacts in the future. Principle one – a strengthened commitment to community engagement. Principle two – better supporting interdisciplinary systems thinking. Principles three – combatting misinformation by enabling enhanced public communication. We believe that today's crises present an opportunity to establish the foundations of a food system transformation that is more equitable, transparent, sustainable, and democratic. HIGHLIGHTS The global agri-food research agenda must adapt to multiple environmental, economic and political disruptions.Three principles can frame a new research agenda: • community engagement • interdisciplinary systems thinking • combatting misinformation Today's crises create an opportunity to enhance the impacts of applied science and support human rights.en© 2025 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Trends in Food Science and Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Trends in Food Science and Technology, vol. 165, art. 105261, pp. 1-3, doi : 10.1016/j.tifs.2025.105261.Food systems transitionsSustainabilityScience policy interfacesSystems thinkingCommunity engagementFood policyPostprint Article