Herd, CandiceMellet, JuanitaMashingaidze, NesterDurandt, ChrisnaPepper, Michael Sean2024-06-132024-06-132023-07-11Herd, C.L., Mellet, J., Mashingaidze, T., Durandt, C. & Pepper, M.S. (2023) Consequences of HIV infection in the bone marrow niche. Frontiers in Immunology. 14:1163012. DOI: 10.3389/fimmu.2023.1163012.1664-3224 (online)10.3389/fimmu.2023.1163012http://hdl.handle.net/2263/96468Dysregulation of the bone marrow niche resulting from the direct and indirect effects of HIV infection contributes to haematological abnormalities observed in HIV patients. The bone marrow niche is a complex, multicellular environment which functions primarily in the maintenance of haematopoietic stem/ progenitor cells (HSPCs). These adult stem cells are responsible for replacing blood and immune cells over the course of a lifetime. Cells of the bone marrow niche support HSPCs and help to orchestrate the quiescence, self-renewal and differentiation of HSPCs through chemical and molecular signals and cell-cell interactions. This narrative review discusses the HIV-associated dysregulation of the bone marrow niche, as well as the susceptibility of HSPCs to infection by HIV.en© 2023 Herd, Mellet, Mashingaidze, Durandt and Pepper. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).Bone marrow nicheHaematopoiesisDysregulationHuman immunodeficiency virus (HIV)Haematopoietic stem/ progenitor cells (HSPCs)SDG-03: Good health and well-beingArticle