Mambwe, DicksonCoertzen, DinaLeshabane, Meta KgaogeloMulubwa, MwilaNjoroge, MathewGibhard, LiezlGirling, GarethWicht, Kathryn J.Lee, Marcus C.S.Wittlin, SergioMoreira, Diogo Rodrigo MagalhaesBirkholtz, Lyn-MarieChibale, Kelly2024-07-252024-07-252024-03Mambwe, D., Coertzen, D., Leshabane, M. et al. 2024, 'hERG, Plasmodium life cycle, and cross resistance profiling of new azabenzimidazole analogues of astemizole', ACS Medicinal Chemistry Letters, vol. 15, no. 4, pp. 463-469, doi : 10.1021/acsmedchemlett.3c00496.1948-5875 (print)10.1021/acsmedchemlett.3c00496http://hdl.handle.net/2263/97228SUPPLEMENTARY INFORMATION : Experimental procedures and characterization data of synthetic intermediates (5a–5f, 6a–6f, 13, and 15) and target compounds (7–12 and 15); biochemical assay protocols, including solubility and cross-resistance studies; H NMR spectra of representative target compounds.Please read abstract in the article.en© 2024 The Authors. Published by American Chemical Society. This article is licensed under CC-BY 4.0.AstemizolePlasmodium falciparumPlasmodium bergheiRepositioningHuman ether-á-go-go-related gene (hERG)GametocytocidalLiver-stage activityResistance phenotypesSDG-03: Good health and well-beingArticle