Dzinamarira, TafadzwaMoyo, EnosMurewanhema, Grant2025-04-162025-04-162025-03Dzinamarira, T.; Moyo, E.; Murewanhema, G. Navigating the Complexities of HIV Prevention for Adolescents and Young Persons: A Science-to-Program and Systems Approach. Adolescents 2025, 5, 1. https://doi.org/10.3390/adolescents5010001.2673-7051 (online)10.3390/adolescents5010001http://hdl.handle.net/2263/102136This article belongs to the Section Adolescent Health and Mental Health.This opinion paper dives into the crucial but challenging space of HIV prevention for adolescents and young persons (AYPs). While their vulnerabilities may be heightened, so too is their potential for resilience, innovation, and positive change. To safeguard their health and empower them to make informed choices, a comprehensive science-to-program and systems approach to HIV prevention is paramount. Recognizing their unique vulnerabilities and immense potential, these authors advocate for a multifaceted approach that bridges the gap between scientific evidence and program implementation within a robust healthcare system. This opinion unpacks how leadership, governance, health policies, human resources, health information systems, and HIV surveillance can be strengthened to create a supportive ecosystem where AYPs have the knowledge, resources, and services they need to thrive. This collective effort, involving policymakers, healthcare providers, educators, and AYPs themselves, is critical to a future where no young person is left behind in the fight against HIV.en© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Human immunodeficiency virus (HIV)Adolescents and youth living with HIV (AYLHIV)HIV preventionLeadershipGovernanceHealth policyHuman resources for health (HRH)Health information systemsHIV surveillanceAdolescents and young persons (AYPs)SDG-03: Good health and well-beingArticle