Reva, Oleg N.Rademan, SunelleVisagie, M.H. (Michelle Helen)Lebelo, Maphuti TebogoGwangwa, Mokgadi VioletKlochko, Vitalii V.Joubert, Anna MargarethaLall, Namrita2019-06-192019-06-192019Reva, O.N., Rademan, S., Visagie, M.H. et al. 2019, 'Comparison of structures and cytotoxicity of mupirocin and batumin against melanoma and several other cancer cell lines', Future Medicinal Chemistry, vol. 11, no. 7, pp. 677-691.1756-8919 (print)1756-8927 (online)10.4155/fmc-2018-0333http://hdl.handle.net/2263/70250AIM : To determine the computer-predicted anticancer activity of mupirocin and to compare its activities with those determined for another polyene antibiotic, batumin. MATERIALS AND METHODS : Molecular docking, cytotoxicity assays, cell microscopy and cell cycle progression were studied in cancer and nontumorigenic cell lines. RESULTS AND CONCLUSION : Cytotoxicity of mupirocin against several cancerous cell lines was detected with the highest one (IC50 = 5.4 μg/ml) against melanoma cell line. The profile of cytotoxicity of mupirocin was similar to that reported for batumin. Nevertheless, the morphology of cells treated with these antibiotics and alterations in cell cycle progression suggested possible dissimilarity in their mechanisms of action. Selective cytotoxicity of mupirocin against melanoma cells potentiates further studies to discover nontoxic drugs for melanoma prevention.en© 2019 Future Science GroupComputer-predicted anticancer activityMupirocinPolyene antibioticBatuminCancer cell linesNontumorigenic cell linesMolecular dockingCell cycle progressionCytotoxicity assaysCell microscopyMelanomaDrug designProphylaxisPreprint Article