Omar, Shaheed VallyJoseph, LavaniaHalima M. SaidIsmail, FarzanaIsmail, NabilaGwala, Thabisile L.Ismail, Nazir Ahmed2020-06-152020-06-152019-02-21Omar SV, Joseph L, Said HM, et al. Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis. African Journal of Laboratory Medicine 2019;8(1), a801. https://DOI.org/10.4102/ajlm.v8i1.801.2225-2002 (print)2225-2010 (online)10.4102/ajlm.v8i1.801http://hdl.handle.net/2263/74994South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome sequencing, followed by bioinformatic analysis using a commercial software package to determine resistance to selected drugs used for Mycobacterium tuberculosis treatment in our setting. Whole genome sequencing shows potential as a diagnostic platform for the detection of drug resistance in Mycobacterium tuberculosis with the provision of information for several drugs simultaneously.en© 2019. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.TreatmentWhole genome sequencingMycobacterium tuberculosis (MTB)Tuberculosis (TB)South Africa (SA)Drug resistanceArticle