Oyagbemi, Ademola AdetokunboHassan, Fasilat OluwakemiAjibade, Temitayo OlabisiOla-Davies, Olufunke EuniceOmobowale, Temidayo OlutayoAjani, Olumide SamuelJarikre, Theophilus AghoghoSoetan, Kehinde OlugboyegaSaba, Adebowale BenardAdedapo, Adeolu AlexAro, Abimbola ObemisolaOyeyemi, Matthew OlugbengaEmikpe, Benjamin ObukowhoNkadimeng, Sanah MalomileMcGaw, Lyndy JoyKayoka-Kabongo, Prudence NgalulaYakubu, Momoh AuduOguntibeju, Oluwafemi Omoniyi2023-10-032023-10-032022-11Oyagbemi, A.A., Hassan, F.O., Ajibade, T.O. et al. 2022, 'Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action', Pakistan Journal of Pharmaceutical Sciences, 35, no. 6, pp. 1581-1694. DOI : 10.36721/PJPS.2022.35.6.REG.1581-1594.1.1011-601X10.36721/PJPS.2022.35.6.REG.1581-1594.1http://hdl.handle.net/2263/92672Launaea taraxacifolia has been traditionally used for the management of conditions such as cardiovascular, respiratory, and metabolic diseases. High blood pressure was established by oral administration of L-Nitro Arginine Methyl Ester (L-NAME) a non-selective inhibitor of endothelial nitric oxide synthase (eNOS). The antihypertensive action of the methanol leaf extract of L. taraxacifolia was examined. Fifty male Wistar rats were divided into 5 groups of 10 animals per group: Group A (Distilled water), Group B (Hypertensive rats; 40mg/kg L-NAME), Group C (Hypertensive rats plus 100 mg/kg extract), Group D (Hypertensive rats plus 200 mg/kg extract) and Group E (Hypertensive rats plus 10mg/kg of Lisinopril). The treatments were orally administered for five weeks. Haemodynamic parameters, urinalysis, indices of oxidative stress and immunohistochemistry were determined. Findings from this study showed that blood pressure parameters, urinary sodium and indices of oxidative stress increased significantly while Invivo antioxidant defence systems decreased significantly in hypertensive rats. Immunohistochemistry revealed significant increases in expressions of mineralocorticoid receptor, angiotensin converting enzyme activity and kidney injury molecule-1 in kidney of hypertensive rats. Treatment with Launeae taraxacifolia normalized blood pressure parameters, urinary sodium, oxidative stress indices, antioxidant defence system, and serum nitric oxide bioavailability.en© University of Karachi.Launaea taraxacifoliaHypertensionOxidative stressAntioxidantAnti-hypertensiveL-Nitro Arginine Methyl Ester (L-NAME)Endothelial nitric oxide synthase (eNOS)SDG-03: Good health and well-beingArticle