Adam, SumaiyaPheiffer, CarmenDias, Stephanie CharmaineRheeder, Paul2019-04-052019-04-052018Adam, S., Pheiffer, C., Dias, S. et al. 2018, 'Association between gestational diabetes and biomarkers : a role in diagnosis', Biomarkers, vol. 23, no. 4, pp. 386-391.1354-750X (print)1366-5804 (online)10.1080/1354750X.2018.1432690http://hdl.handle.net/2263/68921BACKGROUND : We investigated the association between markers of insulin resistance, chronic inflammation, and adipokines and GDM. METHODS : In our case-cohort study in Johannesburg we included women with GDM and controls. We tested the ability of biomarkers to identify women at high risk of GDM. RESULTS : Of the 262 pregnant women, 83 (31.7%) had GDM. Women with GDM were heavier (p = 0.04) and had more clinical risk factors (p = 0.008). We found a significant difference in fasting insulin (p < 0.001), adiponectin (p = 0.046), HOMA (p < 0.001) and QUICKI (p < 0.001). HOMA (AUROC = 0.82) or QUICKI (AUROC = 0.82) improved the ability of risk factors to identify women at high risk of GDM. CONCLUSIONS : Insulin sensitivity markers are promising tools to identify women at high risk of GDM.en© 2018 Informa UK Limited, trading as Taylor & Francis Group. This is an electronic version of an article published in Biomarkers, vol. 23, no. 4, pp. 386-391, 2018. doi : 10.1080/1354750X.2018.1432690. Biomarkers is available online at : http://www.tandfonline.com/loi/ibmk20.ProteinPregnancyAdiponectinWomenType 2 diabetes mellitus (T2DM)Insulin sensitivityBiomarkersGestational diabetes (GDM)Postprint Article