Ncongwane, Jane BusisiweTembu, Vuyelwa JacquelineNkambule, Comfort MduduziKemboi, DouglasFouche, GerdaVukea, NyeletiDe la Mare, Jo-Anne2025-11-262025-11-262025-05-01Ncongwane, J.B.; Tembu, V.J.; Nkambule, C.M.; Kemboi, D.; Fouche, G.; Vukea, N.; de la Mare, J.-A. Labdane Diterpenoids from Leonotis ocymifolia with Selective Cytotoxic Activity Against HCC70 Breast Cancer Cell Line. Diseases 2025, 13, 140. https://doi.org/10.3390/ diseases13050140.2079-9721 (online)10.3390/ diseases13050140http://hdl.handle.net/2263/105521DATA AVAILABILITY STATEMENT : Data are contained within the article and Supplementary Materials. SUPPLEMENTARY MATERIAL : TABLE S1: 1H (δH; J, Hz) NMR (400 MHZ) data for compounds 1–6; TABLE S2: 13C (δc) (100.6 MHz) NMR data for compounds 1-6 and spectral data for compounds 1–6 (APPENDIX 1–27).Please read abstract in the article.en© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Triple-negative breast cancer (TNBC)Leonotis ocymifoliaBreast cancerLabdane diterpenoidsBis-spirolabdaneMCF-7HCC70Cytotoxic activityArticle