Verma, Rahul KumarGermishuizen, Willem AndreasMotheo, M.P. (Mamofalali Portia)Agrawal, Atul KumarSingh, Amit KumarMohan, MradulGupta, PushpaGupta, Umesh DattaCholo, Moloko C.Anderson, RonaldFouche, P. BernardMisra, Amit2014-04-102014-04-102013-02Verma, RK, Germishuizen, WA, Motheo, MP, Agrawal, AK, Singh, AK, Mohan, M, Gupta, P, Gupta, UD, Cholo, M, Anderson, R, Fourie, PB & Misra, A 2013, 'Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice', Antimicrobial Agents and Chemotherapy , vol. 57, no. 2, pp. 1050-1052.0066-4804 (print)1098-6596 (online)10.1128/AAC.01897-12http://hdl.handle.net/2263/39634Inhalable clofazimine-containing dry powder microparticles (CFM-DPI) and native clofazimine (CFM) were evaluated for activity against Mycobacterium tuberculosis in human monocyte-derived macrophage cultures and in mice infected with a low-dose aerosol. Both formulations resulted in 99% killing at 2.5 g/ml in vitro. In mice, 480 g and 720 g CFM-DPI inhaled twice per week over 4 weeks reduced numbers of CFU in the lung by as much as log10 2.6; 500 g oral CFM achieved a log10 0.7 reduction.en© 2013, American Society for Microbiology. All Rights Reserved.MicroparticlesClofazimineTreatmentMiceTuberculosis -- Treatment -- ResearchArticle