Camara, DjenebBisanz, CordeliaBarette, CarolineVan Daele, JeroenHuman, EsmareBarnard, BerniceVan der Straeten, DominiqueStove, Christophe P.Lambert, Willy E.Douce, RolandMarechal, EricBirkholtz, Lyn-MarieCesbron-Delauw, Marie-FranceDumas, RenaudRebeille, Fabrice2012-10-022012-10-022012-05Camara, D, Bisanz, C, Barette, C, Van Daele, J, Human, E, Barnard, B, Van der Straeten, D, Stove, CP, Lambert, WE, Douce, R, Marechal, E, Brikholtz, LM, Cesbron-Delauw, MF, Dumas, R & Rebeille, F 2012, 'Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine', Journal of Biological Chemistry, vol. 287, no. 26, pp. 22367-22376.0021-9258 (print)1083-351X (online)10.1074/jbc.M112.365833http://hdl.handle.net/2263/19945BACKGROUND: pABA biosynthesis is a potential target for antifolate drugs. RESULTS: Rubreserine inhibits GAT-ADCS, an enzyme involved in pABA biosynthesis, and decreased the folate content in Arabidopsis and Toxoplasma. CONCLUSION: Specific inhibition of pABA synthesis induces growth limitation of plants and apicomplexan parasites. SIGNIFICANCE: GAT-ADCS is a valuable target in eukaryotes, and rubreserine is a novel scaffold for anti-parasitic drugs.en© 2012 by The American Society for Biochemistry and Molecular Biology, Inc. This research was originally published: Camara, D; Bisanz, C; Barette, C; Van Daele, J; Human, E; Barnard, B; Van Der Straeten, D; Stove, CP; Lambert, WE; Douce, R; Marechal, E; Birkholtz, LM; Cesbron-Delauw, MF; Dumas, R; Rebeille, F, Inhibition of p-aminobenzoate and folate syntheses in plants and apicomplexan parasites by the natural product rubreserine, Journal of Biological Chemistry, 2012, vol. 287, pp 22367-22376.pABA biosynthesisGAT-ADCSFolateArabidopsisApicomplexaPostprint Article