Atkinson, Brogan KimThompson, P.N. (Peter N.)Van Zyl, EsteeGoddard, AmeliaRautenbach, YolandiSchoeman, Johan P.Mukorera, VaraidzoLeisewitz, Andrew L.2022-11-022022-11-022022-07-19Brogan Kim Atkinson, Peter Thompson, Estee Van Zyl, Amelia Goddard, Yolandi Rautenbach, Johan Petrus Schoeman, Varaidzo Mukorera, Andrew Leisewitz, The dataset for the inflammatory response during experimental infection and treatment of dogs with Babesia rossi, Data in Brief, Volume 45, 2022, ISSN 2352-3409, https://doi.org/10.1016/j.dib.2022.108475.2352-3409 (online)10.1016/j.dib.2022.108475https://repository.up.ac.za/handle/2263/88078Babesia rossi causes severe morbidity and mortality in dogs in sub-Saharan Africa. This was an experimental study designed to observe systemic changes caused by Babesia rossi infection within a canine disease model as well as investigate the influence of inoculum dose and treatment on the progression of inflammation and clinical disease. Six healthy male beagle dogs formed the study population, one dog was splenectomised and used to raise the infectious inoculum, three were administered a high B. rossi infectious dose and two a low infectious dose. Clinical examination, complete blood count (CBC) and C-reactive protein (CRP) were determined daily. Cytokines were quantified on stored plasma collected during the study, using a canine specific cytokine magnetic bead panel (Milliplex©). The experiment was terminated, and treatment administered once predetermined experimental or humane endpoints were reached. The data and information provided in the following article is the summary of all dataen© 2022 Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).CytokinesC-reactive proteinLeukocytesTreatmentParasitemiaAnaemiaBabesia rossiArticle