Lauritzen, Hilde B.Larose, Tricia L.Oien, TorbjornSandanger, Torkjel M.Odland, Jon OyvindVan de Bor, MargotJacobsen, Geir W.2018-02-092018-02-092018-01-18Lauritzen, H.B., Larose, T.L., Oien, T. et al. 2018, 'Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up : a prospective cohort study', Environmental Health, vol. 17, art. no. 9, pp. 1-12.1476-069X10.1186/s12940-017-0338-xhttp://hdl.handle.net/2263/63914Additional file 1: Supplementary figures, tables and information.BACKGROUND : Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies. METHODS : Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986–88, and analyses of two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) were conducted. We used linear and logistic regression models with 95% confidence intervals (CIs) to evaluate the associations between maternal serum POP concentrations at 17–20 weeks of gestation and child overweight/obesity (body mass index (BMI) ≥ 85th percentile) at 5-year follow-up. Results were further stratified by country after testing for effect modification. We also assessed potential non-monotonic dose-response (NMDR) relationships. RESULTS : In adjusted linear models, we observed increased BMI-for-age-and-sex z-score (β = 0.18, 95% CI: 0.01–0.35), and increased triceps skinfold z-score (β = 0.15, 95% CI: 0.02–0.27) in children at 5-year follow-up per ln-unit increase in maternal serum perfluorooctane sulfonate (PFOS) concentrations. We observed increased odds for child overweight/obesity (BMI ≥ 85th percentile) for each ln-unit increase in maternal serum PFOS levels (adjusted OR: 2.04, 95% CI: 1.11–3.74), with stronger odds among Norwegian children (OR: 2.96, 95% CI: 1.42–6.15). We found similar associations between maternal serum perfluorooctanoate (PFOA) concentrations and child overweight/obesity. We found indications of NMDR relationships between PFOS and polychlorinated biphenyl (PCB) 153 and child overweight/obesity among Swedish children. CONCLUSION : We found positive associations between maternal serum PFAS concentrations and child overweight/obesity at 5-year follow-up, particularly among Norwegian participants. We observed some evidence for NMDR relationships among Swedish participants.en© The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).Perfluoroalkyl substancesOrganochlorinesChildhood obesityNon-monotonic dose-response relationshipPregnancyEndocrine disrupting chemicalsSkinfoldsPlasmaTricepsPregnancyAdolescentsRiskObesityPostnatal growthSkinfold thicknessEndocrine disrupting chemicalsBody mass index (BMI)Article