Bunn, Belinda KathleenVan Heerden, Willem Francois Petrus2016-04-212016-04-212015-03Bunn, BK & Van Heerden, WFP 2015, 'EBV-positive mucocutaneous ulcer of the oral cavity associated with HIV/AIDS', Oral Surgery Oral Medicine Oral Pathology Oral Radiology, vol. 120, no. 6, pp. 725-732.2212-4403 (print)2212-4411 (online)10.1016/j.oooo.2015.06.028http://hdl.handle.net/2263/52084OBJECTIVE : To present two cases of Epstein-Barr virus (EBV)-positive mucocutaneous ulcer of the oral mucosa in association with human immunodeficiency virus infection. STUDY DESIGN : Two recently diagnosed cases of EBV-positive mucocutaneous ulcer of the oral mucosa in HIV-positive patients were reviewed with regards to their clinical, histomorphological and immunophenotypic features. RESULTS : Both cases presented clinically as well circumscribed ulcers which were histomorphologically characterized by dense superficial polymorphous inflammatory infiltrates. The infiltrates comprised cells with a predominant B-cell phenotype which ranged in size from small to intermediate with occasional large immunoblastic forms. Some of the larger B-cells had a Reed-Sternberg-like morphology. The B-cells were positive for CD20 and co-expressed CD30 and to a lesser extent CD15. EBER positivity was detected in most of the B-cells. CONCLUSION : EBV-positive mucocutaneous ulcer represents an unusual form of lymphoproliferative disorder associated with immune suppression. It should be distinguished from other forms of HIV-associated oral ulceration.en© 2015 Elsevier Inc. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. A definitive version was subsequently published in Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 120, no. 6. pp. 725-732, 2015. doi : 10.1016/j.oooo.2015.06.028.EBV-positiveMucocutaneous ulcerOral cavityAssociated with HIV/AIDSEpstein-Barr virus (EBV)Human immunodeficiency virus (HIV)Acquired immune deficiency syndrome (AIDS)Postprint Article